中文名 | rac-Vigabatrin Hydrochloride |
英文名 | rac-Vigabatrin Hydrochloride |
别名 | 盐酸氨己烯酸 氨己烯酸盐酸盐 4-氨基-5-己烯酸盐酸盐 VIGABATRIN(中间体) |
英文别名 | Vigabatrin HCL SABRIL HYDROCHLORIDE Vigabatrin (Hydrochloride) γ-Vinyl-GABA hydrochloride Γ-VINYL-GABA HYDROCHLORIDE rac-Vigabatrin Hydrochloride 4-aminohex-5-enoic acid hydrochloride |
CAS | 1391054-02-6 |
化学式 | C6H12ClNO2 |
分子量 | 165.61798 |
存储条件 | 2-8℃ |
体外研究 | A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin. |
体内研究 | Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 6.038 ml | 30.19 ml | 60.379 ml |
5 mM | 1.208 ml | 6.038 ml | 12.076 ml |
10 mM | 0.604 ml | 3.019 ml | 6.038 ml |
5 mM | 0.121 ml | 0.604 ml | 1.208 ml |